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Coupled NAD + /NADH redox exert their main effect in mitochondria, by serving as an electron donor through ETC for oxidative phosphorylation and producing cellular ROS (Li and Sauve 2015), but they also exhibit protective effects by enhancing GSH levels and the activity of antioxidant enzymes (Wang et al

The meta-analysis showed that blood concentrations of oxidative glutathione (GSSG), malondialdehyde, homocysteine, S -adenosylhomocysteine, nitric oxide, and copper were higher in children with ASD than that of HC children

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